ImmuneTree vs NewZealand Colostrum

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Colostrum:Immune-Tree vs. New Zealand colostrum

Dear consumer,

As a qualified business and technical consultant with considerable experience in this field, I amwriting to present pertinent facts regarding the composition of New Zealand colostrum and tointroduce you to colostrum products distributed by Immune-Tree, which I have found to besubstantially superior.

My qualifications are derived from more than twenty-five years of senior management experiencewith Fortune 500 companies that develop, manufacture and market a variety of human and animalhealthcare products, including diverse biologicals. I subsequently founded two biotechnology firms,one of which was focused in agribusiness, and, since 1986, have served as a business and technologyconsultant to many small and medium-sized companies in the human and animal healthcare fields.For the last ten years, a number of my clients have been focused on the human and animalapplications of bovine colostrum and I have personally been responsible for highly diverse fieldstudy and testing programs with these materials, including licensure of products through the USDA.In addition, I have served as an expert witness in court cases based upon colostrum-associatedissues. I hold a Ph.D. in Immunochemistry from Rutgers University.

During the last 5-7 years, dairy science has developed a deeper understanding of what bovinecolostrum actually is and how it is formed. Numerous studies have now shown that colostrumformation in the cow begins several weeks prior to birth, accelerates as parturition nears and ceasesupon the birth of the calf. At the time of birth, almost all of the biologically active componentspresent in the udder were transferred from the circulation of the mother, while most substancesfound in later fluids are produced by cells within the udder itself. These factors, combined with thetime of collection after birth, play a major role in establishing the quality of bovine colostrum.Removal of even a small quantity of colostrum immediately after birth, as would occur via suckling,results in a very substantial influx of a different fluid produced by the cells in the udder, known astransitional milk, markedly diluting the true colostrum. In addition, if the true colostrum is notremoved from the udder during the first 6-8 hours after birth of the calf, the mother's system beginsto reabsorb the biologically active components back into her circulation. Therefore, the onlycolostrum that contains all of the biologically active components in the appropriate proportions isthat which is obtained at the first milking within six hours after birth. Major American dairyproducers are keenly aware of this and most maintain maternity wards, separate from the main herd,to support the birth of their calves. They no longer allow the calf to suckle, but, rather, collectthe complete colostrum within hours after birth and feed an adequate quantity to the calf. Thiscontrasts sharply to the old-fashioned open pasture birthing methods applied in some other parts ofthe world, such as New Zealand, wherein the calf invariably receives an inadequate quantity ofcolostrum to effectively support its development and unnecessarily exposes it to a variety of diseasecausingmicroorganisms.

A comparison of the characteristics of the colostrums used to formulate products from Symbioticsand Immune-Tree in light of the above discussion reflects the first major difference. Symbioticsloudly promotes that their colostrum is derived entirely from pasture-fed cows in New Zealand, thatthe calf is allowed to suckle after birth, and that collections from the first to fifth milkings are used.Immune-Tree uses only colostrum from cows in controlled domestic herds that have been certifiedto meet Grade A standards for milk and has been obtained only at the first milking within six hoursafter birth of the calf.

IGF-1 is a very important component of bovine colostrum that conveys significant benefits whenthe material is consumed by humans. The maximum amount of this component occurs in true firstmilking colostrum obtained within six hours after birth. Data from a study conducted by theEndocrinology Laboratory, College of Veterinary Medicine, Cornell University, comparing the IGF-1 levels in various lots of products from these manufacturers clearly reflects the impact of thedifferent collection methods on product quality. The products from Immune-Tree yielded consistentvalues that reflected a high quality colostrum while the values observed with the Symbiotics'products were inconsistent and, in some cases, were approximately 50% lower than what would beobtained with properly collected first milking bovine colostrum.

IGF-1Manufacturer Form (ng/ml)Complete Colostrum Liquid 499.10Immune-Tree Capsule 432.92Capsule 453.14Powder 456.94Powder 436.74Symbiotics Capsule 413.00Capsule 228.86Powder 295.80Powder 274.70

Another major difference between the products marketed by Immune-Tree and Symbiotics isreflected in their chemical composition. This was directly compared in a head-to-head studyconducted at Minnesota Valley Testing Laboratories, a premier dairy testing laboratory. Acomparative assessment of protein, fat, lactose, casein and albumin content was done on multiplelots of the products. These components were selected since their concentrations and relationshipschange with time after birth and, thus, are indicative of the quality of the colostrum used in aproduct.

The data clearly show the differences between these products. The chemical composition of theImmune-Tree products is almost identical to that of the reference colostrum preparation, while theproducts from Symbiotics show almost no similarity. These findings reflect Symbiotics' claim thatthey remove most of the fat from their colostrum during processing since they believe that itcontributes nothing to the composition and its presence leads to increased rancidity and productdeterioration. These statements are contrary to accepted scientific findings. First, colostral fatcontains several fat-associated and fat-soluble components that are beneficial and are removed upondefatting the material. In addition, increased rancidity due to fat content is a characteristicassociated with liquid preparations. There are numerous studies that demonstrate the protractedshelf-life of properly dried colostrum preparations without the development of rancidity.It should also be noted that removal of the fat component will cause a shift in the chemical profileof the product, creating the illusion that it contains a lot of protein. This occurs because the valuesare reported based upon the amount of total solids present. In reality, the powders from Symbioticscontain less total protein than the other tested materials.

One additional factor of note is the relationship between the amounts of casein and albumin in thesepreparations. After birth, cells in the udder begin to produce more casein than albumin and the ratioof these components will shift with time such that the ratio of casein to albumin will exceed 1.0 atabout 8-12 hours after birth. The data indicate that the colostrum used to produce the referencepreparation and the products from Immune-Tree were collected within 6 hours after birth whilethe colostrum used to produce the Symbiotics products was obtained an average of more than 24hours after birth.

I hope that you found this information to be useful and that you will give due consideration to thecolostrum products distributed by Immune-Tree. As a business man, I am sure that you share myconcern about the rhetorical claims made by companies that have little or no basis in actual scientificfact and that you also find them confusing.

To your good health - always.

Sincerely,

Alfred E. Fox, Ph.D.

Dr. Alfred E. Fox holds a Ph.D. from Rutgers University in Microbiology (Immunochemistry) andhas more than 25 years of senior management experience at Carter-Wallace, Baxter Dade Divisionand Warner-Lambert, where he was responsible for research and development and regulatoryaffairs. He was also the founder and president of two biotechnology companies focused onagribusiness and environmental monitoring, respectively. For the past 15 years, Dr. Fox has beenthe President of Fox Associates, a business and technology consulting firm serving small- to midsizecompanies in the human and animal healthcare fields. He focuses primarily on marketing andregulatory issues and for the past 10 years has continuously consulted to bovine colostrummanufacturers, where he has gained regulatory approval for their products, been a technicaladvisor, helped design and develop marketing strategies and served as an expert witness in legalmatters.

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